Symptoms and treatment for overdose and antidote(s): Management of acute poisoning with NSAIDs consists essentially of supportive and symptomatic measures. Overdosage of diclofenac produces no typical clinical picture. Supportive and symptomatic treatments are indicated for complications, e.g. hypotension, renal failure, convulsions, gastrointestinal irritation and respiratory depression.
It is unlikely that specific measures, e.g., forced diuresis, dialysis or haemoperfusion are helpful in eliminating nonsteroidal antirheumatic agents owing to their high protein-binding rate and extensive metabolism.